Having lost to Leicester before being beaten by League Two Colchester in the Carabao Cup, Spurs’ spirits were lifted as £53.8m club record signing Tanguy Ndombele scored with a powerful deflected finish.
Serge Aurier, who had already been booked, was sent off in the 32nd minute for a foul on Ryan Bertrand after Spurs felt the ball had gone out of play just before.
In an enthralling match, Southampton were gifted an equaliser after Lloris was dispossessed inside his own six-yard area by Danny Ings following a back pass.
But Harry Kane then swept home what proved to be the winner after an assist by Christian Eriksen.
Spurs captain Lloris went someway to redeeming himself for his howler with two excellent second-half saves.
He flung himself across his line to keep out James Ward-Prowse’s free-kick before producing an acrobatic leap to block Maya Yoshida’s header following a corner.
Having made a slow start to the season, this was a welcome victory for Mauricio Pochettino’s side, who had started the day closer to the relegation zone than a Champions League spot.
After dropping 10 points from their previous six matches, they will be relieved to have returned to winning ways even if it was a far from convincing performance.
Lloris had been forced to save from Pierre-Emile Hojbjerg before France midfielder Ndombele lashed home his second goal since joining from Lyon in July.
Spurs’ season has been anything but straightforward and, having developed a nasty habit of throwing away leads, they once again gifted their opponents a way back at Tottenham Hotspur Stadium.
